Antagonistic Effects of Chinese Salt and Folic Acid on Developing Swiss Albino Mice:  Antagonistic Effects of Chinese Salt and Folic Acid

Ata Ul Mustafa Fahid; Azeem Azam; Hamza Faseeh; Farhan Anjum; Rabia Bano; Maryam Latif; Sana Kauser

doi:10.54393/mjz.v4i02.76

Authors

Ata Ul Mustafa Fahid Institute of Zoology, Punjab University, Lahore, Pakistan
Azeem Azam Institute of Zoology, Punjab University, Lahore, Pakistan
Hamza Faseeh Institute of Zoology, Punjab University, Lahore, Pakistan
Farhan Anjum Institute of Zoology, Punjab University, Lahore, Pakistan
Rabia Bano Department of Zoology, Division of Science University of Education, Lahore, Pakistan
Maryam Latif Institute of Zoology, Punjab University, Lahore, Pakistan
Sana Kauser Department of Zoology, Division of Science University of Education, Lahore, Pakistan

DOI:

https://doi.org/10.54393/mjz.v4i02.76

Keywords:

Albino Mice, Folic Acid, Chinese Salt

Abstract

One of the most often utilized taste enhancer in commercial meals is monosodium glutamate (MSG) commonly called Chinese salt. MSG utilization has been increasing over time and linked with toxicity in liver and other organs. Objective: To determine the teratogenic and toxic effects of Chinese salt and folic acid on developing mice. Methods: In this study, 20 female pregnant albino mice were divided into four groups, each consisted 5 mice. The control group was supplied with water. To check the teratogenicity and toxicity of Chinese salt and folic acid the treated groups such as Group-I, Group-II and Group-III were supplied with Chinese salt and/or folic acid of concentration 7.50 ug/g of their body weight. The dose was administered orally on daily basis during 6^th to 12^th day of gestation. This was accomplished through an 18 days trial. On the eighteenth day of gestation, the pregnant mice underwent dissection and the fetuses were retrieved. Fetuses were taken from all groups for histopathological findings and morphometry. Results: Vast range of morphological, morphometric and histological abnormalities in mice were observed in pregnant mice and fetuses. Conclusions: The findings of this study clearly revealed that Chinese salt and folic acid overdose are potentially toxic to liver and stomach.

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