Biological Uses and Importance of Iron Regulation
Iron regulation
DOI:
https://doi.org/10.54393/mjz.v1i1.12Abstract
Iron is an exceedingly important nutrient of the human body that has the ability to proceed the formation of free radicals and helps in the process of redox cycling with many different roles in metastasis and in microenvironment. It is required for many complex biological processes occurring in cells and inevitable for its viability and human survival. Such processes include oxygen transportation within body, cell proliferation and growth. It produces free radicals and has redox cycling capacity which may be responsible for tumorigenesis as well. Iron metabolic pathways are new therapeutic strategies for improving cancer prognosis and treatment as reprogramming of iron metabolism is a key aspect for tumor cells growth and survival.
References
Severinghaus JW. Oxyhemoglobin dissociation curve correction for temperature and pH variation in human blood. J Appl Physiol, 1958, 12(3): 485-486. doi: 10.1152/jappl.1958.12.3.485.
Rajendran R, Vijayakumar T et al. An alternative pathogenetic pathway for oral submucous fibrosis (OSMF). Med Hypotheses, 1989, 30(1): 35-37. doi: 10.1016/0306-9877(89)90122-9.
Hunter T. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell, 1995, 80(2): 225-236, doi: 10.1016/0092-8674(95)90405-0.
Mascotti DP, Rup D et al. Regulation of iron metabolism: translational effects mediated by iron, heme, and cytokines. Annu Rev Nutr, 1995, 15: 239-261. doi: 10.1146/annurev.nu.15.070195.001323.
von Drygalski A and Adamson JW. Iron Metabolism in Man. JPEN J Parenter Enteral Nutr., 2012. doi: 10.1177/0148607112459648.
Torti SV and Torti FM. Iron and cancer: more ore to be mined. Nat Rev Cancer, 2013, 13(5): 342-355. doi: 10.1038/nrc3495.
Donovan A, Brownlie A et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature, 2000, 403(6771): 776-781. doi: 10.1038/35001596.
Fleming RE and Bacon BR. Orchestration of iron homeostasis. N Engl J Med, 2005, 352(17): 1741-1744. doi: 10.1056/NEJMp048363.
Frazer DM and Anderson GJ. Iron imports. I. Intestinal iron absorption and its regulation. Am J Physiol Gastrointest Liver Physiol, 2005, 289(4): G631-635. doi: 10.1152/ajpgi.00220.2005.
Fleming RE and Britton RS. Iron Imports. VI. HFE and regulation of intestinal iron absorption. Am J Physiol Gastrointest Liver Physiol, 2006, 290(4): G590-594. doi: 10.1152/ajpgi.00486.2005.
Blanc JF, Bioulac-Sage P et al. [Iron overload and cancer]. Bull Acad Natl Med,2000, 184(2): 355-363.
D'Souza G, Kreimer AR et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med, 2007, 356(19): 1944-1956.doi: 10.1056/NEJMoa065497
Jian J, Yang Q et al. Effects of iron deficiency and iron overload on angiogenesis and oxidative stress-a potential dual role for iron in breast cancer. Free Radic Biol Med, 2011, 50(7): 841-847. doi: 10.1016/j.freeradbiomed.2010.12.028.
Andrews NC. Disorders of iron metabolism. N Engl J Med, 1999, 341(26): 1986-1995.doi: 10.1056/NEJM199912233412607
Conrad ME and Umbreit JN. Disorders of iron metabolism. N Engl J Med,2000, 342(17): 1293-1294.
Pacher P, Beckman JS et al. Nitric oxide and peroxynitrite in health and disease. Physiol Rev, 2007, 87(1): 315-424. doi: 10.1152/physrev.00029.2006.
Manivasagam T, Anantharaman P et al. Chemopreventive effect of Padina boergesenii extracts on ferric nitrilotriacetate (Fe-NTA)-induced oxidative damage in Wistar rats. J. Appl. Phycol., 2011, 23(2): 257 (252): 257–263. doi.org/10.1007/s10811-010-9564-0
Green R, Charlton R et al. Body iron excretion in man: a collaborative study. Am J Med, 1968, 45(3): 336-353. Body iron excretion in man: a collaborative study.
Vellar OD. Studies on sweat losses of nutrients. II. The influence of an oral iron load on the iron content of whole body cell-free sweat. Scand J Clin Lab Invest, 1968, 21(4): 344-346. doi.org/10.3109/00365516809077004
Brune, M., B. Magnusson, et al. Iron losses in sweat. Am J Clin Nutr, 1986, 43(3): 438-443. doi: 10.1093/ajcn/43.3.438.
DeRuisseau KC, Cheuvront SN et al. Sweat iron and zinc losses during prolonged exercise. Int J Sport Nutr Exerc Metab, 2000, 12(4): 428-437. doi: 10.1123/ijsnem.12.4.428.
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